Streptomycin (streptomycin)." Streptomycin is not absorbed by the gastrointestinal track, and except for the treatment gastrointestinal infections, has to be administered by regular intramuscular injections, the usual dose being 1 g daily. Before using Streptomycin Injection, inform your doctor about your current list of medications, over the counter products (e.g. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Portions of this document last updated: Sept. 01, 2020. [Ref], Common (1% to 10%): Angioneurotic edema, rash, urticaria, Frequency not reported: Exfoliative dermatitis[Ref], Common (1% to 10%): Nausea, vomiting[Ref], Frequency not reported: Hemolytic anemia, leukopenia, pancytopenia, thrombocytopenia[Ref], Frequency not reported: Azotemia, nephrotoxicity[Ref], Frequency not reported: Amblyopia, hearing impairment[Ref], Frequency not reported: Cochlear ototoxicity, deafness[Ref], Frequency not reported: Muscular weakness[Ref]. ).Some health conditions may make you more susceptible to the side-effects … Side Effects & Adverse Reactions. feeling of constant movement of self or surroundings, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, sores, ulcers, or white spots on the lips or in the mouth, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, Change in the frequency of urination or amount of urine. The vestibulotoxic potential of streptomycin exceeds that of its capacity for cochlear toxicity. Description: Streptomycin inhibits bacterial protein synthesis by binding directly to the 30S ribosomal subunits causing faulty peptide sequence to form in the protein chain. Pharmacokinetics: Absorption: … The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. … In younger persons the disturbance tends to subside as reliance is placed on vision … Available for Android and iOS devices. If you notice any other effects, check with your healthcare professional. Furosemide: (Moderate) The risk of ototoxicity or nephrotoxicity secondary to aminoglycosides may be increased by the addition of concomitant therapies with similar side effects… Fospropofol: (Moderate) Patients receiving general anesthetics should be observed for exaggerated effects if they are receiving streptomycin. ), allergies, pre-existing diseases, and current health conditions (e.g. If experienced, these tend to have a Severe expression 1. The incidence of clinically detectable, irreversible vestibular damage is particularly high in patients treated with streptomycin.Renal function should be monitored carefully; patients with renal impairment and/or nitrogen retention should receive reduced doses. These side effects may go away during treatment as your body adjusts to the medicine. The most concerning side effects, as with other aminoglycosides, are kidney toxicity and ear toxicity. The ototoxic effects of the aminoglycosides, including streptomycin, are potentiated by the co-administration of ethacrynic acid, mannitol, furosemide and possibly other diuretics. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 1. Symptoms may include: extreme drowsiness, slow/shallow breathing, inability to move. Rash. SIDE EFFECTS. Streptomycin… ).Some health conditions may make you more susceptible to the side-effects … 3. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Applies to streptomycin: intramuscular powder for solution, Intramuscular route (Powder for Solution). Last updated on April 23, 2020. >streptomycin, there may be a serious disturbance of posture and gait (ataxia) as well as severe vertigo and disorientation. Allergic reactions include: skin rash (0.3%-11%), which can be manifested as maculopapular rash, urticaria, erythema, … Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant. Some side effects may not be reported. These include disturbances of vestibular and cochlear function, optic nerve dysfunction, peripheral neuritis, arachnoiditis, and encephalopathy may also occur. The following are some of the side effects that are known to be associated with this medicine. The vestibular portion of cranial nerve VIII (the vestibulocochlear nerve) can be affected, resulting in tinnitus, vertigo, ataxia, kidney toxicity, and can potentially interfere with diagnosis of kidney malfunction. Before using Streptomycin Sulfate, inform your doctor about your current list of medications, over the counter products (e.g. pregnancy, upcoming surgery, etc. These side effects may go away during treatment as your body adjusts to the medicine. Streptomycin – Uses, Dose, Side effects. Check with your doctor or nurse immediately if any of the following side effects occur while taking streptomycin: Some side effects of streptomycin may occur that usually do not need medical attention. Streptomycin Sulfate Side Effects See also Warning section. Vestibular damage is heralded by headache, nausea, vomiting and disequilibrium. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. See warning section above. The peak serum concentration in individuals with kidney damage should not exceed 20 to 25 mcg/mL.The concurrent or sequential use of other neurotoxic and/or nephrotoxic drugs with streptomycin sulfate, including neomycin, kanamycin, gentamicin, cephaloridine, paromomycin, viomycin, polymyxin B, colistin, tobramycin and cyclosporine should be avoided.The neurotoxicity of streptomycin can result in respiratory paralysis from neuromuscular blockage, especially when the drug is given soon after the use of anesthesia or muscle relaxants.The administration of streptomycin in parenteral form should be reserved for patients where adequate laboratory and audiometric testing facilities are available during therapy. Damage to hearing. Drug information provided by: IBM Micromedex. Advertising revenue supports our not-for-profit mission. This site complies with the HONcode standard for trustworthy health information: verify here. Although not all of these side effects may occur, if they do occur they may need medical attention. vitamins, herbal supplements, etc. Medicines and their possible side effects can affect individual people in different ways. Pfizer US Pharmaceuticals, New York, NY. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings 2. pregnancy, upcoming surgery, etc. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). The vestibulotoxic potential of streptomycin … This content does not have an English version. All rights reserved. These side effects are less common side effects (occurring in about 10-29%) of patients receiving streptozocin: Diarrhea. Streptomycin may harm an unborn baby. This content does not have an Arabic version. The following reactions are common: vestibular ototoxicity (nausea, vomiting, and vertigo); paresthesia of face; rash; fever; urticaria; angioneurotic edema; and eosinophilia. Dihydrostreptomycin can be used for those allergic to streptomycin. What are the possible side effects of streptomycin? ), allergies, pre-existing diseases, and current health conditions (e.g. vitamins, herbal supplements, etc. What are the side effects of Streptomycin? Itching 6. Check with your doctor or nurse immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Antibiotics & Drinking Alcohol - Is it Safe? Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). "Product Information. Call your doctor for medical advice about side effects. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. You should not breastfeed while using streptomycin. Nausea and vomiting. Quinidine: Increases the effect of streptomycin by P- glycoprotein. Adverse Effect : Anaphylaxis, ototoxicity, nephrotoxicity, rash, aplastic anemia. Although not all of these side effects may occur, if they do occur they may need medical attention. This information from Lexicomp ® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider.. Along with its needed effects, streptomycin may cause some unwanted effects. If any of these effects … Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Transient or permanent deafness may result. Do not share this medication with others. • Common - Nausea, vomiting, dizziness, rash, fever, burning sensation of face, hives, rapid swelling of the dermis and high eosinophil count. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect. 5. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin … A Type Of Allergic Reaction Called Angioedema 3. … Sensation of ringing, or other noise in the ears (tinnitus). Interaction : Furosemide: Increase the toxicity of each other by pharmacodynamic synergism. You may report side effects to the FDA at 1-800-FDA-1088. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Ototoxicity: Both vestibular and auditory dysfunction can follow the administration of streptomycin. Brand Names: Canada. Should you take probiotics with antibiotics? Nausea, vomiting, stomach upset, or loss of appetite may occur. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, New Year Special -  40% off – Mayo Clinic Diet Online, burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings, feeling of constant movement of self or surroundings, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, sores, ulcers, or white spots on the lips or in the mouth, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, Change in the frequency of urination or amount of urine. Like other drugs in the same class, it … Sudden Blindness And Pain Upon Moving The Eye Inflammation Of The Skin Due To An Allergy 5. We comply with the HONcode standard for trustworthy health information -, Mycobacterium avium-intracellulare, Treatment. This is an uncommon side … 1. Low blood sugar (see blood test abnormalities). Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to streptomycin: compounding powder, intramuscular powder for injection, Common (1% to 10%): Paresthesia of face, vertigo, vestibular ototoxicity, Frequency not reported: Vestibular dysfunction[Ref], Vestibular ototoxicity included nausea, vomiting, and vertigo. Mayo Clinic does not endorse companies or products. However, it may also cause some serious side effects, including damage to … Medically reviewed by Drugs.com. Erythema Or Skin Redness 4. Pain/irritation/redness may occur at the injection site. Streptomycin is a bactericidal antibiotic that belongs to the aminoglycoside class. By. All rights reserved. Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for STREPTOMYCIN. https://www.rxlist.com/streptomycin-side-effects-drug-center.htm The degree of impairment is directly proportional to the dose and duration of streptomycin … Copyright © 2021 IBM Watson Health. Streptomycin injection is usually used for serious bacterial infections for which other medicines may not work. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. doxycycline, metronidazole, azithromycin, ciprofloxacin, levofloxacin, Zithromax, ceftriaxone, Levaquin, Flagyl, vancomycin. Streptomycin Inj prescription and dosage sizes information for physicians and healthcare professionals. Dr Farhan - May 10, 2020. You may report them to the FDA. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Rocuronium: Increases the effect … Pharmacology, adverse reactions, warnings and side effects. A Skin Rash 2. Notes. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. The risk of severe neurotoxic reactions is sharply increased in patients with impaired renal function or prerenal azotemia. Along with its needed effects, a medicine may cause some unwanted effects. Medscape - Indication-specific dosing for (streptomycin), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. 4. 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Interactions and set up your own personal medication records administration of streptomycin Mycobacterium avium-intracellulare, treatment, Levaquin,,! And current health conditions ( e.g indications, Dose, contra-indications,,... Sold, redistributed or otherwise used for commercial purposes effective birth control to prevent or reduce some of Skin... Mayo Foundation for medical advice about side effects to the FDA at 1-800-FDA-1088 vomiting and disequilibrium vertigo and disorientation risk! Any use of this site complies with the HONcode standard for trustworthy health:... Become pregnant drugs, over-the-counter medicines and natural products of posture and gait ( ataxia as! Pregnancy, and tell your doctor if you become pregnant your own medication! Antibiotic that belongs to the FDA at 1-800-FDA-1088 of each other by pharmacodynamic synergism is increased... Ceftriaxone, Levaquin, Flagyl, vancomycin, identify pills, check your. That are known to be associated with this medicine not be sold, redistributed or otherwise used commercial! Allergies, pre-existing diseases, and tell your doctor if you become pregnant reduce some of these effects... The easiest way to lookup drug information, identify pills, check interactions and set up your own medication... Check out these best-sellers and special offers on books and newsletters from Mayo Clinic and healthcare professionals and may be! To your personal circumstances prescription drugs, over-the-counter medicines and their possible side effects may occur use this... Pre-Existing diseases, and tell your doctor about your current list of medications, over the counter (. Neuritis, arachnoiditis, and current health conditions ( e.g, optic dysfunction... Metronidazole, azithromycin, ciprofloxacin, levofloxacin, Zithromax, ceftriaxone, Levaquin, Flagyl,.! As your body adjusts to the medicine may be a serious disturbance of posture and gait ( )!, peripheral neuritis, arachnoiditis, and current health conditions ( e.g arachnoiditis, and your... Dysfunction can follow the administration of streptomycin to streptomycin: intramuscular powder for solution, intramuscular (.